Introduction to ARA-290
ARA-290 is a synthetic peptide derived from erythropoietin (EPO), designed for preclinical research exploring cellular signaling pathways involved in inflammation, tissue repair, and metabolic regulation. It has been investigated in non-human models for its potential role in modulating immune responses, neuropathic mechanisms, and glucose-related biomarkers.
Mechanism of Action (Research-Based)
In experimental models, ARA-290 interacts with tissue-protective receptors (TPRs)—a non-erythropoietic receptor complex expressed on immune cells such as macrophages, mast cells, dendritic cells, and lymphocytes. This interaction has been associated with:
Reduced release of pro-inflammatory cytokines (e.g., IL-6)
Improved cellular resilience in inflammatory conditions
Preservation of islet cell viability, which plays a key role in glycemic regulation studies
Neuroprotective signaling, potentially supporting pain modulation and nerve recovery models
Key Research Areas (Preclinical Use Only)
ARA-290 is under investigation in in vitro and animal models in the following research domains:
Metabolic Studies: Evaluated for effects on glucose regulation and lipid profiles
Neuropathic Pain Models: Studied for modulation of pain signaling pathways in experimental neuropathy
Inflammatory Regulation: Explored for anti-inflammatory signaling via TPR interaction
Tissue Repair & Wound Healing: Assessed in models of skin and soft tissue injury
Immunomodulation: Investigated for its role in cytokine balance and immune cell response
⚠️ Disclaimer: ARA-290 is intended for laboratory research use only. It is not for human consumption, not for diagnostic or therapeutic use, and has not been evaluated by the FDA or other regulatory agencies for clinical application. Use only under appropriate institutional research protocols and biosafety guidelines.
Certificate of Analysis
| Property | Description |
|---|---|
| Chemical Sequence | Ala-Glu-Asp-Leu |
| CAS | 158152-06-2 |
| Molecular Formula | C17H29N5O6 |
| Molecular Weight | Approximately 403.44 g/mol |
| Appearance | White Lyophilized Powder |
Research Use Only:
ARA-290 is intended strictly for in vitro testing and laboratory experimentation. It is not intended for human or animal medical use. It is not a drug, food, or cosmetic and should not be misbranded, misused, or mislabeled as such
