GHRP-2 5mg Peptide (For Research Use Only)
Introduction to GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide developed for laboratory research into growth hormone (GH) modulation. It belongs to the GHRP family and has been widely studied for its effects on endogenous GH release via the ghrelin receptor pathway. The compound has shown promise in preclinical models evaluating endocrine function, metabolism, and tissue regeneration.
GHRP-2’s mechanism of action, receptor selectivity, and short duration make it a valuable tool in biochemical and physiological studies of growth hormone regulation and associated downstream effects.
⚠️ GHRP-2 is not approved for human or veterinary use. It is intended strictly for laboratory research applications.
Mechanism of Action
GHRP-2 binds to GHS-R1a (growth hormone secretagogue receptor type 1a), a receptor also activated by the endogenous ligand ghrelin. Upon binding, it stimulates the pituitary gland to release growth hormone, independent of hypothalamic GHRH (Growth Hormone-Releasing Hormone). This action is synergistic when combined with GHRH analogs, a characteristic frequently explored in dual-administration research protocols.
Key downstream mechanisms observed in laboratory settings include:
Activation of the cAMP-PKA pathway
Lipolytic activity (fat metabolism)
Modulation of insulin sensitivity and IGF-1 levels
Potential impact on glucose metabolism and appetite signaling
Key Research Areas
GHRP-2 has been widely used in non-human research models to investigate:
GH axis stimulation mechanisms
Protein synthesis and muscle tissue modeling
Adipose tissue metabolism (lipolysis vs. lipogenesis)
The role of GH in post-injury tissue repair
Appetite regulation pathways (via ghrelin mimicry)
Age-related hormonal decline models
When studied alongside GHRH analogs (e.g., CJC-1295), GHRP-2 has helped researchers explore combined peptide synergy and receptor co-activation dynamics.
Comparative Peptide Profile
Peptide | GH Secretion | Appetite Effect | Receptor Target | Known Research Focus Areas |
---|---|---|---|---|
GHRP-2 | High | Mild/Moderate | GHS-R1a | GH stimulation, tissue regeneration |
GHRP-6 | Moderate | Strong | GHS-R1a | GH stimulation, appetite studies |
Ipamorelin | Moderate | Minimal | GHS-R1a | Targeted GH release, minimal side effects |
Disclaimer
GHRP-2 is supplied strictly for in vitro studies and laboratory research. It is not approved by the FDA, EMA, or other regulatory agencies for human consumption or therapeutic use. Researchers must handle all peptides with appropriate PPE and in accordance with institutional biosafety protocols.
Certificate of Analysis
Property | Description |
Chemical Sequence | H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 |
CAS | 158861-67-7 |
Molecular Formula | C45H55N9O6 |
Molecular Weight | 817.9749 g/mol |
CID | 6918245 |
Appearance | White Lyophilized Powder |
Learn More About GHRP-2
- “Growth Hormone Releasing Peptide-2 (GHRP-2), Like Ghrelin, Increases Food Intake in Healthy Men”
- “Growth hormone-releasing peptide-2 – University of Maryland, Baltimore”
- “Effects of GHRP-2 and Cysteamine Administration on Growth … – PLOS”
- “Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing …”