Introduction to GHRP-6 (Growth Hormone Releasing Peptide-6)
GHRP-6 is a synthetic hexapeptide composed of the amino acid sequence His-D-Trp-Ala-Trp-D-Phe-Lys, developed for laboratory research use only. It is part of the growth hormone-releasing peptide (GHRP) family, which is studied for its ability to stimulate endogenous growth hormone (GH) secretion via interaction with the growth hormone secretagogue receptor (GHS-R1a).
This compound has been of interest in preclinical studies focused on metabolism, appetite regulation, tissue regeneration, and muscle protein synthesis. Its activity is ghrelin-mimetic, meaning it acts on the same receptor pathway as the natural hormone ghrelin.
Mechanism of Action
GHRP-6 functions by binding to ghrelin receptors (GHS-R1a) located in the hypothalamus and pituitary gland. This interaction activates signaling pathways that result in the secretion of endogenous growth hormone. The peptide’s action is independent of GHRH but synergistic when co-administered in research models.
In addition to stimulating GH release, GHRP-6 has demonstrated the ability to:
Increase IGF-1 levels in certain test systems
Modulate glucose and insulin sensitivity in metabolic models
Influence appetite signaling pathways, notably through orexigenic effects
Its short half-life and potent pulsatile stimulation make it valuable for temporal GH studies and receptor activation profiling.
Key Research Areas
GHRP-6 has been utilized in various in vitro and animal model studies to investigate:
Anabolism and muscle regeneration mechanisms
Lipolysis and fat metabolism pathways
Appetite stimulation in cachexia or caloric restriction models
Wound healing and collagen synthesis
GH/IGF-1 axis modulation
It has also been co-administered with other peptides such as CJC-1295 in laboratory models to explore synergistic effects on hormone release dynamics.
Safety and Compliance Statement
GHRP-6 is not approved for human or veterinary use. It is intended solely for laboratory research and in vitro studies. Any off-label or non-research usage is strongly discouraged and may violate local regulatory guidelines.
Certificate of Analysis
| Property | Description |
| Chemical Sequence | L-His-D-Tryp-L-Ala-L-Tryp-, D-Phen-L-Lys |
| CAS | 87616-84-0 |
| Molecular Formula | C46H56N12O6 |
| Molecular Weight | 873.032 |
| CID | 5486806 |
| Appearance | White Lyophilized Powder |
Learn More About GHRP-6
Sure, here are five peer-reviewed articles about the benefits of GHRP-6:
- “Growth hormone-releasing peptide-6”
- “Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects”
- “Growth hormone releasing peptide-6 (GHRP-6) prevents – Frontiers”
- “Frontiers | Growth hormone releasing peptide-6 (GHRP-6) prevents …”
