Kisspeptin 10mg

What is Kisspeptin?

Kisspeptin is a neuropeptide derived from the KISS1 gene, acting as a potent regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It is primarily used in research to study reproductive health, hormonal regulation, and fertility due to its ability to stimulate gonadotropin-releasing hormone (GnRH) release, which triggers luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. Kisspeptin 10 mg refers to a synthetic decapeptide fragment (kisspeptin-10), administered as a lyophilized powder for reconstitution or, in some cases, as an oral formulation (though typically injectable).

Mechanism of Action

Kisspeptin binds to the KISS1 receptor (GPR54) in the hypothalamus, stimulating GnRH release, which activates the pituitary gland to secrete LH and FSH. These gonadotropins regulate:

• Testosterone Production: LH stimulates Leydig cells in the testes (males) or theca cells in the ovaries (females) to produce testosterone or estrogen, respectively, enhancing reproductive function and anabolic processes.
• Spermatogenesis/Ovulation: FSH supports sperm production in males and follicular development in females, critical for fertility.
• Appetite and Metabolism: Indirectly influences appetite and weight via hormonal effects on testosterone (anabolic, appetite-stimulating in males) and energy homeostasis, though direct appetite effects are minimal.
• Neuroendocrine Regulation: Modulates puberty onset, sexual behavior, and mood via hypothalamic signaling.

Unlike direct testosterone therapies, kisspeptin upregulates endogenous hormone production, avoiding HPG axis suppression, making it a promising research tool for fertility, hypogonadism, and hormonal optimization.

Clinical Efficacy and Benefits

Clinical and preclinical research highlights kisspeptin’s efficacy in hormonal regulation, fertility, and reproductive health, with secondary benefits for muscle growth and weight gain via testosterone-mediated anabolism. Key findings include:

• Hormonal Stimulation:
  • Men: Single doses of kisspeptin-10 (0.01–3 nmol/kg IV) increased LH by ~2–5-fold and testosterone by ~20–30% within 2–4 hours in healthy men (Dhillo et al., 2005). Subcutaneous doses (0.1–10 µg/kg) sustained LH/FSH release over 24 hours.
  • Women: Enhanced LH/FSH surges in premenopausal women, supporting ovulation in infertility studies (Jayasena et al., 2014).
• Fertility:
  • Improved ovulation rates in women with hypothalamic amenorrhea, with ~60% achieving follicular maturation at 10 µg/kg twice daily for 2 weeks (Jayasena et al., 2010).
  • Enhanced sperm parameters in hypogonadal men, with potential for male infertility treatment.
• Muscle Growth (Indirect):
  • Testosterone elevation promotes protein synthesis and muscle hypertrophy, with anecdotal reports of 0.5–1 kg lean mass gain in 8–12 weeks when combined with resistance training, though direct anabolic effects are weaker than SARMs or steroids.
• Weight Gain (Indirect):
  • Testosterone’s anabolic effects support lean mass gain (~0.5–1.5 kg in 12 weeks) in hypogonadal men, with minimal fat accumulation. Appetite may increase mildly via testosterone’s metabolic effects, but kisspeptin lacks direct ghrelin-like hunger stimulation.
• Other Benefits:
  • Mood and Libido: Improves sexual motivation and mood via dopamine and testosterone pathways, enhancing quality of life.
  • Bone Health: Supports bone density via testosterone/estrogen, relevant for hypogonadism or osteoporosis research.
  • Metabolic Health: Improves insulin sensitivity and glucose metabolism in preclinical models, with potential for type 2 diabetes research.

Certificate of Analysis

Kisspeptin 10mg – COA – FYP

Learn More About Kisspeptin

• “Kisspeptin-10 stimulates gonadotropin release in healthy men” (Dhillo et al., J Clin Endocrinol Metab, 2005).
• “Kisspeptin restores ovulation in women with hypothalamic amenorrhea” (Jayasena et al., J Clin Invest, 2014).
• “Kisspeptin: A novel regulator of reproductive function” (Endocrine Reviews, 2009).
• “Therapeutic potential of kisspeptin in infertility and hypogonadism” (Nature Reviews Endocrinology, 2013).
• “Kisspeptin’s role in puberty and metabolism” (Journal of Endocrinology, 2016).