Introduction to SNAP-8
SNAP-8 is a synthetic octapeptide developed to support cosmetic and dermatological research, particularly in the study of facial expression-related wrinkle formation. As a derivative of SNAP-25, a component of the SNARE complex involved in neurotransmitter release, SNAP-8 is structurally designed to modulate facial muscle contractions through non-invasive mechanisms. It is considered a next-generation analog of Argireline (Acetyl Hexapeptide-8), offering improved potency and broader application potential in topical formulations under investigation.
This peptide has gained interest in laboratory research related to skin aging, neuromuscular signaling pathways, and biomimetic anti-aging technologies. SNAP-8 is not a drug or therapeutic product and is not approved for clinical use.
Mechanism of Action
SNAP-8 operates by competing with endogenous SNAP-25 at the SNARE complex, a molecular mechanism responsible for vesicle docking and neurotransmitter (acetylcholine) release. By interfering with vesicle fusion, SNAP-8 has been observed in vitro to reduce neuromuscular transmission efficiency, resulting in diminished contraction of superficial facial muscles.
This mechanism is of particular interest in models studying dynamic wrinkle formation, where overexpression of SNAP-8 leads to partial muscle relaxation without full neuromuscular blockade. Compared to Botulinum Toxin (Botox), which cleaves SNAP-25, SNAP-8 preserves structural integrity while modulating functionality, allowing researchers to investigate subtler and safer wrinkle-relaxing mechanisms.
Key Research Areas
SNAP-8 is a synthetic peptide fragment of SNAP-25 and is utilized in non-clinical research settings, primarily in the exploration of peptide-based modulation of neurotransmitter release and dermal applications. Investigative areas include:
Topographical Wrinkle Modeling: Used in in vitro systems and ex vivo skin models to measure structural changes in dermal matrix over time.
Synaptic Vesicle Dynamics: Studied for its potential to inhibit SNARE complex formation, impacting vesicular neurotransmitter release in preclinical models.
Neuromodulatory Peptide Screening: Evaluated alongside other short-chain peptides in muscle relaxation assays under non-human experimental conditions.
Topical Delivery Optimization: SNAP-8 is incorporated into delivery systems such as microneedles, liposomes, and nanoemulsions in formulation-based research.
Combination Peptide Synergy: Frequently used in comparative or synergistic peptide screens, including combinations with Leuphasyl, Matrixyl, and humectants like hyaluronic acid.
Observations in Non-Human and In Vitro Studies
The following outcomes have been reported in preclinical, in vitro, or ex vivo studies and do not imply suitability for human application or therapeutic use:
Up to 63% reduction in wrinkle-like depth observed in synthetic skin models after 28 days of peptide exposure.
Demonstrated approximately 30% greater surface relaxation than Argireline under identical assay conditions.
Enhanced firmness and elasticity observed when combined with collagen-stimulating agents in laboratory models.
Non-paralytic muscle fiber relaxation in vitro, supporting safety research in non-invasive model systems.
Improved moisture retention reported in ex vivo skin samples when co-formulated with known humectants.
For Research Use Only. Not for Human or Veterinary Use.
SNAP-8 is not approved by the FDA for use in humans. All data cited are from preclinical or laboratory-based research and should not be interpreted as clinical claims or recommendations.
Certificate of Analysis
The following technical details outline the properties of SNAP-8 10mg, providing a scientific snapshot of the peptide.
Property | Description |
|---|---|
Chemical Sequence | Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
CAS Number | 868844-74-0 |
Molecular Formula | C41H70N16O16S |
Molecular Weight | 1075.16 g/mol |
Appearance | White Lyophilized Powder |
Research Use Only
SNAP-8 10mg is intended strictly for in vitro laboratory use and formulation testing under controlled research conditions. It is not for human use, ingestion, injection, or cosmetic application outside of validated scientific models. This product is not a drug, food, or cosmetic and must not be misbranded or repurposed in violation of applicable research regulations.
