Introduction
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic research compound frequently used in experimental studies to investigate cellular energy regulation. It functions as an activator of AMP-activated protein kinase (AMPK), a key enzyme involved in monitoring and managing cellular energy status. Due to its influence on metabolic pathways, AICAR is commonly employed in laboratory settings to explore mechanisms related to energy metabolism, cellular stress response, and metabolic adaptation under various physiological and pathological conditions.
Key Research Areas of AICAR 50mg
AICAR’s role as an AMPK activator has made it a valuable tool in a variety of preclinical and in vitro research domains:
Metabolic Pathways: Facilitates investigation into glucose uptake, insulin signaling, and lipid oxidation, supporting experimental models of metabolic dysregulation.
Cardiometabolic Studies: Used to evaluate AMPK-related responses in cardiovascular tissues and cellular models, including effects on lipid metabolism and energy balance.
Mitochondrial Function: Frequently applied in studies exploring mitochondrial biogenesis, oxidative phosphorylation, and cellular adaptation to energy stress.
Neurobiological Research: Utilized in experimental models to study AMPK’s role in neuronal survival, autophagy, and neuroinflammation.
Inflammation Modulation: Applied in research investigating AMPK-mediated pathways in cytokine expression and inflammatory signaling.
Disclaimer: This material is intended for research use only. It is not approved for human consumption or therapeutic applications. Use is limited to qualified laboratories and institutional research settings.
Certificate of Analysis
Property | Description |
|---|---|
Chemical Name | 5-Aminoimidazole-4-carboxamide ribonucleotide |
CAS Number | 2627-69-2 |
Molecular Formula | C9H14N4O6P |
Molecular Weight | 338.2 g/mol |
Appearance | White to off-white lyophilized powder |
Purity | ≥98% (HPLC) |
Solubility | Soluble in water |
Storage | Store at -20°C in a dry place, protected from light |
Learn More About AICAR
AICAR: A Review of Its Potential Therapeutic Applications – Overview of AICAR’s mechanisms and potential in metabolic and cardiovascular research (Diabetes Journals).
The Role of AICAR in Exercise Performance and Recovery – Explores AICAR’s effects on endurance and mitochondrial function (USADA).
AMPK Activation by AICAR: Implications for Cancer Therapy – Discusses broader applications, including potential in cancer research (PMC).
