Introduction to PE-22-28 10mg
PE-22-28 is a synthetic 7-amino-acid peptide derived from spadin, a naturally occurring peptide from sortilin. It acts as a potent inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore potassium channel implicated in mood regulation and neuroprotection. With an IC50 of 0.12 nM, PE-22-28 shows higher specificity and affinity for TREK-1 compared to spadin (40–60 nM), making it a promising candidate for research into depression, cognitive function, and stroke recovery.
Key Research Areas of PE-22-28 10mg
PE-22-28 is a synthetic peptide analog of spadin, primarily studied for its interaction with TREK-1 potassium channels—ion channels known to regulate neuronal excitability and signal transmission in the prefrontal cortex, hippocampus, and amygdala. Experimental research involving in vivo and in vitro models has identified several areas of interest:
TREK-1 Modulation: Investigated for its capacity to regulate mood-related behaviors and neuronal firing patterns through TREK-1 inhibition in rodent models.
Behavioral Neuroscience Models: In murine studies, sub-chronic administration of PE-22-28 resulted in reduced immobility in forced swim tests and shortened latency in novelty-suppressed feeding assays, commonly used endpoints in the evaluation of antidepressant-like responses.
Synaptic Plasticity: Experimental findings show increased PSD-95 expression in cultured cortical neurons, suggesting a role in promoting synaptic development and plasticity in cellular models.
Post-Ischemic Studies: In stroke-related animal models, PE-22-28 has been used to examine long-term recovery effects, including modulation of post-injury mood-related behaviors.
Neuroprotection: Ongoing research explores its potential to buffer neurons from excitotoxic stress, aiding studies into neurodegenerative disease mechanisms and neuroinflammatory pathways.
Cognitive Function Research: Preliminary data suggest effects on learning and memory pathways via neurotransmitter system modulation in controlled laboratory settings.
Disclaimer: PE-22-28 is intended for preclinical research use only. It is not approved for human or veterinary consumption, diagnosis, or treatment. Use is restricted to qualified professionals in laboratory environments.
Certificate of Analysis
Property | Description |
|---|---|
Chemical Name | Glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine |
CAS Number | 1801959-12-5 |
Molecular Formula | C35H55N11O9 |
Molecular Weight | 773.8947 g/mol |
Appearance | White lyophilized powder |
Purity | ≥99% (HPLC) |
Solubility | Soluble in bacteriostatic water |
Storage | Store at -20°C before reconstitution; 2–8°C after |
Learn More About PE-22-28
Shortened Spadin Analogs and TREK-1 Inhibition – Details PE-22-28’s superior affinity and stability compared to spadin, with applications in depression research (PMC).
PE-22-28 for Neuroprotection and Cognitive Enhancement – Explores its role in neurogenesis and stroke recovery (Limitless Life).
Role of TREK-1 in Health and Disease – Reviews TREK-1’s significance in neurological health and PE-22-28’s potential (Frontiers).
