Introduction to PE-22-28 10mg
PE-22-28 is a synthetic 7-amino-acid peptide derived from spadin, a naturally occurring peptide from sortilin. It acts as a potent inhibitor of TREK-1 (TWIK-related potassium channel), a two-pore potassium channel implicated in mood regulation and neuroprotection. With an IC50 of 0.12 nM, PE-22-28 shows higher specificity and affinity for TREK-1 compared to spadin (40–60 nM), making it a promising candidate for research into depression, cognitive function, and stroke recovery.
Benefits of PE-22-28 10mg
PE-22-28 is primarily recognized for its potential to modulate TREK-1 channels, which regulate neuronal excitability in brain regions like the prefrontal cortex, amygdala, and hippocampus. Key research benefits include:
Antidepressant Activity: In mouse models, PE-22-28 reduced immobility time in the forced swimming test and latency to eat in the novelty-suppressed feeding test after 4-day sub-chronic treatment, indicating rapid antidepressant effects (PMC).
Neurogenesis and Synaptogenesis: Enhances neuron growth and synaptic plasticity, increasing PSD-95 expression in mouse cortical neurons, potentially supporting cognitive health (PMC).
Stroke Recovery: Chronic treatment improved post-stroke recovery in mice, reducing depressive behaviors months after ischemia (Limitless Life).
Cognitive Enhancement: May improve learning, memory, and focus by modulating neurotransmitter pathways (LIVV Natural).
Neuroprotection: Protects neurons from excitotoxicity, potentially aiding research into neurodegenerative diseases like Alzheimer’s (Peptide Sciences).
Benefit | Description | Research Context |
|---|---|---|
Antidepressant Activity | Reduces depressive behaviors in animal models | Depression research |
Neurogenesis | Promotes neuron growth and synaptic plasticity | Cognitive health studies |
Stroke Recovery | Improves post-stroke outcomes | Neurological recovery research |
Cognitive Enhancement | Enhances learning, memory, and focus | Cognitive function studies |
Neuroprotection | Shields neurons from excitotoxicity | Neurodegenerative disease research |
Certificate of Analysis
Property | Description |
|---|---|
Chemical Name | Glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine |
CAS Number | 1801959-12-5 |
Molecular Formula | C35H55N11O9 |
Molecular Weight | 773.8947 g/mol |
Appearance | White lyophilized powder |
Purity | ≥99% (HPLC) |
Solubility | Soluble in bacteriostatic water |
Storage | Store at -20°C before reconstitution; 2–8°C after |
Learn More About PE-22-28
Shortened Spadin Analogs and TREK-1 Inhibition – Details PE-22-28’s superior affinity and stability compared to spadin, with applications in depression research (PMC).
PE-22-28 for Neuroprotection and Cognitive Enhancement – Explores its role in neurogenesis and stroke recovery (Limitless Life).
Role of TREK-1 in Health and Disease – Reviews TREK-1’s significance in neurological health and PE-22-28’s potential (Frontiers).
