Introduction to SLU-PP-332
SLU-PP-332 is a synthetic small molecule developed as a potent, non-selective agonist of estrogen-related receptors (ERRs), showing the highest activity for ERRα (EC50 = 98 nM), followed by ERRβ (EC50 = 230 nM) and ERRγ (EC50 = 430 nM). Originally synthesized at Saint Louis University School of Medicine (reflected in the “SLU” prefix), this compound is designed to activate ERR pathways associated with metabolic regulation, without exhibiting estrogenic effects. SLU-PP-332 is primarily used in laboratory research to study potential metabolic benefits analogous to those induced by aerobic exercise, with applications under investigation for obesity, type 2 diabetes, metabolic syndrome, and neurodegenerative conditions.
Key Research Areas
In animal models, including diet-induced obese and genetically obese (ob/ob) mice, SLU-PP-332 has been shown to:
Enhance fatty acid oxidation
Decrease fat mass
Improve insulin sensitivity
Increase exercise endurance by up to 70%
As of 2025, SLU-PP-332 remains in preclinical development, with no regulatory approval for human use. Research is ongoing to explore its pharmacokinetics, oral bioavailability, and safety profile.
Research Findings and Potential Benefits
Based on preclinical and in vitro studies, SLU-PP-332 has demonstrated the following research-relevant effects:
Fat Reduction: Significant decreases in fat mass without affecting appetite or requiring exercise
Improved Metabolic Markers: Enhanced glucose tolerance and insulin signaling in animal models
Increased Endurance: Improved exercise capacity correlating with mitochondrial adaptations
Enhanced Mitochondrial Function: Increased cellular respiration and ATP production in muscle cell lines
Cardiovascular Research Potential: Preservation of cardiac function in disease models
Neuroprotection: Early studies suggest possible benefits in neurodegenerative disease models
Renal Support: Indirect improvements in kidney health through metabolic regulation
Certificate of Analysis
The following technical details outline the properties of SLU-PP-332 5mg, based on available data.
Property | Description |
|---|---|
Chemical Name | (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide |
CAS Number | 303760-60-3 |
Molecular Formula | C18H14N2O2 |
Molecular Weight | 290.32 g/mol |
Appearance | White to Off-White Crystalline Powder |
Research Use Only: SLU-PP-332 is intended exclusively for in vitro and animal laboratory research. It is not approved for human or veterinary use and should not be marketed or labeled as a drug, supplement, or food product.
